许燕 副研究员，博士研究生导师，博士毕业于中国科学院大学，2017年通过中山大学“百人计划”加入新葡亰8883ent。在体细胞重编程和肝脏疾病发生机制等方面以第一作者/通讯作者在Cell Stem Cell, Journal of Hepatology, Nature Materials, Trends in Cell Biology等国际权威期刊发表学术论文多篇，研究获得国家重点研发计划、国家自然科学基金、广东省自然科学基金等基金支持。

研究方向及意义：

1.干细胞分化机制及其在肝脏疾病治疗中的作用与机制研究；

2.肝脏再生修复中的表观遗传和转录调控机制研究。

代表性研究成果：

1. Huaxin Chen^#, JianyeCai^#, Jiancheng Wang^#, Yuan Qiu, Chenhao Jiang, Yi Wang, Guo lv, Lijie Pan, Yuanjun Guan, Jun Zheng, DongboQiu, Cong Du, Qiuli Liu, Guihua Chen, Yang Yang^*, Yan Xu^*, Andy Peng Xiang^*,Qi Zhang^*. Targeting Nestin-positive hepatic stellate cells ameliorates liver fibrosis by modulating Caveolin-mediated TβRI degradation. Journal of Hepatology.2021 May;74(5):1176-1187.
2. Qiuli Liu^#, Xiaoyong Chen^#, Chang Liu^#, Lijie Pan, Xinmei Kang, Yanli Li, Cong Du, Shuai Dong, Andy Peng Xiang^*, Yan Xu^*, Qi Zhang^*. Mesenchymal Stem Cells Alleviate Experimental Immune-mediated Liver Injury via Chitinase 3-like protein 1-mediated T cell suppression. Cell Death Dis. 2021 Mar 4;12(3):240.
3. Yan Xu, Qi Zhang. Chapter 15 - Clinical Application of Stem Cells in Liver Diseases: From Bench to Bedside. Stem Cells and Cancer in Hepatology: From the Essentials to Application. https://doi.org/10.1016/C2016-0-03399-5, Pages 317-346 (2018).
4. Yan Xu^#, Meng Zhang^#, Wenjuan Li, Xihua Zhu, XichenBao, Baoming Qin, Andrew P Hutchins^*, Miguel A Esteban^*. Transcriptional Control of Somatic Cell Reprogramming. Trends Cell Biol. 2016 Apr;26(4):272-288.
5. Longqi Liu^#, Yan Xu^#, *, Minghui He^#, Meng Zhang, Fenggong Cui, Leina Lu, Mingze Yao, WeihuaTian, Christina Benda, QiangZhuang, Zhijian Huang, Wenjuan Li, Xiangchun Li, Ping Zhao, Wenxia Fan, ZhiweiLuo, Yuan Li, Yasong Wu, Andrew P Hutchins, Dongye Wang, Hung-Fat Tse, Axel Schambach, Jon Frampton, Baoming Qin, XichenBao, Hongjie Yao, Biliang Zhang, Hao Sun, Duanqing Pei, Huating Wang, Jun Wang, Miguel A Esteban^*. Transcriptional pause release is a rate-limiting step for somatic cell reprogramming. Cell Stem Cell. 2014 Nov 6;15(5):574-88.
6. Yan Xu, Longqi Liu, Andrew L Laslett, Miguel A Esteban. Cell reprogramming: Into the grooveNat Mater. 2013 Dec;12(12):1082-4. doi: 10.1038/nmat3821.
7. Cancan Xu, Zhuowei Zhou, Chang Liu, Xinmei Kang, XiaofenZhong, Qi Zhang^⁎, Yan Xu^⁎. Generation of a DAPK1 knockout first (conditional ready) human embryonic stem cell line (ZSSYe001-A) by CRISPR-Cas9 technology. Stem Cell Research 43, March 2020.
8. Huijiao Wu^#, Cong Du^#, Fan Yang^#, XiaofangZheng, DongboQiu, Qi Zhang, Wenjie Chen^*, Yan Xu^*. Generation of hepatocyte-like cells from human urinary epithelial cells and the role of autophagy during direct reprogramming. BiochemBiophys Res Commun. 2020 Jun 30;527(3):723-729.
9. MIGUEL ANGEL ESTEBAN BARRAGAN、秦宝明、鲍习琛、刘龙奇、许燕、吴海涛、朱细华、郭享彭、吴亚松、李媛、庄强、卿小兵、骆志伟、黄颖华、张辉，尿液诱导多能干细胞技术及体细胞重编程机制，广东省自然科学奖，一等奖，2019年，中国科学院广州生物医药与健康研究院

其他学术活动：

1. 中国机械工程学会生物制造工程分会第二届委员会委员
2. Frontiers in Cell and Developmental Biology杂志Guest editor，负责research topic“Targeting Heterogeneity of Mesenchymal Stem Cells”的编辑；
3. 担任Molecular Therapy - Nucleic Acids，Stem Cell Research & Therapy，Frontiers in Cell and Developmental Biology，Cell Biology and Toxicology，World Journal of Surgical Oncology，Medical Science Monitor等杂志审稿人。