从事骨科临床工作十余年，专注于微创脊柱外科领域。擅长骨质疏松症及其相关性椎体骨折、腰椎间盘突出、腰椎管狭窄、腰椎滑脱、颈椎病等退行性疾病，以及脊柱感染和脊柱创伤骨折等脊柱疾病的诊断及微创手术治疗。

新葡亰8883ent脊柱外科 副主任医师，硕士生导师

本科毕业于中南大学湘雅医学院，在中山大学获得硕士及博士学位。

已发表的学术论著 (#equal contribution,*corresponding author)

1. Shangfu Li#*, Qiuli Liu#, Depeng Wu#, Tianwei He, Jinbo Yuan, HengQiu, Jennifer Tickner, Song GuoZheng, Xiaojuan Li, JiakeXu*, LiminRong*. PKC-delta deficiency in B cells displays osteopenia accompanied with upregulation of RANKL expression and osteoclast-osteoblast uncoupling, Cell death & disease 2020; 11(9): 762. (IF=8.469)
2. Shangfu Li#*, Tianwei He#, Depeng Wu#, Liangming Zhang, Ruiqiang Chen, Bin Liu, Jinbo Yuan, Jennifer Tickner, An Qin, JiakeXu, LiminRong*. Conditional Knockout of PKC-delta in Osteoclasts Favors Bone Mass Accrual in Males Due to Decreased Osteoclast Function, Frontiers in cell and developmental biology, 2020; 8: 450. (IF=6.684)
3. Shangfu Li, Ruiqiang Chen, Yuyong Chen, Guoshu Mo, Liangming Zhang, FengFeng, Bu Yang, PeigenXie, Qiyou Wang, Bin Liu, Jianwen Dong, LiminRong*. Therapeutic effects and safety of percutaneous disc decompression with coblationnucleoplasty in cervical vertigo: A retrospective outcome study with 74 consecutive patients and minimum 1-year follow-up, Pain Physician 2019; 22(3): E205-E214. (IF=4.965)
4. Shangfu Li#, Bu Yang#, Dian Teguh, Lin Zhou, Jiake Xu, Limin Rong*. Amyloid beta Peptide Enhances RANKL-Induced Osteoclast Activation through NF-kappaB, ERK, and Calcium Oscillation Signaling. International journal of molecular sciences 2016; 17(10). (IF=5.923)
5. Shangfu Li#, Bin Liu#, Ming Tian, Liangming Zhang, Jennifer Tickner, Jiake Xu, Limin Rong *. An effective and practical immunohistochemical protocol for bone specimens characterized by hyaluronidase and pepsin predigestion combined with alkaline phosphatase -mediated chromogenic detection. Histology and Histopathology 2015; 30(3):331-43. (IF=2.303)
6. Shangfu Li, Bin Liu, Liangming Zhang, Limin Rong*. Amyloid beta peptide is elevated in osteoporotic bone tissues and enhances osteoclast function.Bone 2014; 61: 164-175. (IF=4.398)
7. Bu Yang#, Shangfu Li#, Zheng Chen#, FengFeng, Lei He, Bin Liu, Tianwei He, Xuan Wang, Ruiqiang Chen, Zihao Chen, PeigenXie*, LiminRong*. Amyloid beta peptide promotes bone formation by regulating Wnt/beta-catenin signaling and the OPG/RANKL/RANK system, FASEB Journal 2020; 34(3): 3583-3593. (IF=5.191)
8. Lin Zhou#, Guoju Hong#, Shangfu Li#, Qian Liu, Fangming Song, Jinmin Zhao, Jinbo Yuan, Jennifer Tickner, JiakeXu*. Fangchinoline protects against bone loss in OVX mice via inhibiting osteoclast formation, bone resorption and RANKL-induced signaling, International journal of biological sciences 2020; 16(2): 309-319. (IF=6.580)
9. Tianwei He#, Depeng Wu#, Lei He#, Xuan Wang, Bu Yang, Shangfu Li, Yuyong Chen, Kun Wang, Ruiqiang Chen, Bin Liu, Liangming Zhang, LiminRong. Casein kinase 1 epsilon facilitates cartilage destruction in osteoarthritis through JNK pathway. FASEB journal 2020; 34(5): 6466-6478. (IF=5.191)
10. Zihao Chen#, Liangming Zhang#, Jianwen Dong, PeigenXie, Bin Liu, Qiyou Wang, Ruiqiang Chen, Tao Shu, Shangfu Li, FengFeng, Bu Yang, Lei He, Yang Yang, Zhongyu Liu, Mao Pang, LiminRong*. Percutaneous Transforaminal Endoscopic Discectomy VersusMicroendoscopic Discectomy for Lumbar Disc Herniation: Two-Year Results of a Randomized Controlled Trial. Spine 2019; 45(8): 493-503. (IF=3.468)
11. Zihao Chen#, Liangming Zhang#, Jianwen Dong, PeigenXie, Bin Liu, Qiyou Wang, Ruiqiang Chen, FengFeng, Bu Yang, Tao Shu, Shangfu Li, Yang Yang, Lei He, Mao Pang, LiminRong*. Percutaneous transforaminal endoscopic discectomy compared with microendoscopic discectomy for lumbar disc herniation: 1-year results of an ongoing randomized controlled trial. Journal of neurosurgery. Spine 2018; 28(3): 300-310. (IF=3.602)
12. Chang Liu#, Yong Huang#, Mao Pang#, Yang Yang, Shangfu Li, Linshan Liu, Tao Shu, Wei Zhou, Xuan Wang, Limin Rong*, Bin Liu*. Tissue-engineered regeneration of completely transected spinal cord using induced neural stem cells and gelatin-electrospunpoly(lactide-co- glycolide)/polyethylene glycol scaffolds. Plos one 2015; 10(3): e0117709. (IF=3.240)
13. Wei Zhou#, Peigen Xie#, Mao Pang#, Bu Yang, Youqiang Fang, Tao Shu, Chang Liu, Xuan Wang, Liangming Zhang, Shangfu Li, Limin Rong*. Upregulation of CRMP4, a new prostate cancer metastasis suppressor gene, inhibits tumor growth in a nude mouse intratibial injection model. Int J Oncol 2015; 46: 290-298. (IF=5.650)

以主持人和核心成员身份获得的科研资助项目（按时间倒序排列）

广东省自然科学基金面上项目，PKC-δ通过雄激素受体信号通路性别依赖性调控雄鼠破骨细胞骨吸收功能的机制研究，项目负责人，编号2021A1515010316，2021.01-2023.12，10万

广州市科技计划市校（院）联合资助项目，PKC-δ介导B细胞分泌RANKL导致破骨细胞-成骨细胞失藕联及骨丢失的骨免疫学机制研究，项目负责人，编号202102010187，2021.04-2023.03，20万

国家自然科学基金面上项目，CK1ε通过Wnt/JNK通路促进骨性关节炎软骨退变的作用及其机制研究，排名第三，编号81972111，2020.01-2023.12，55万

广东省科技创新战略专项基金自由申请项目，抗痴呆药物Donepezil治疗骨质疏松作用及其抑制骨吸收的机制研究，项目负责人，编号2018A030313248，2018.05-2021.04，10万

新葡亰8883ent临床研究计划启航项目，经皮髓核成形术治疗颈性眩晕临床疗效和安全性的单中心、随机对照、前瞻性队列研究，项目负责人，编号QHJH201809，2018.03-2020.03，5万

中山大学高校基本科研业务费—青年教师培育项目，破骨细胞PKC-δ基因条件性敲除后骨吸收功能改变及其分子机制，项目负责人，编号17ykpy49，2017.01-2019.12，15万

广东省自然科学基金-博士科研启动项目，β-淀粉样蛋白通过过度激活破骨细胞与加速成骨细胞凋亡促进骨质疏松发展的机制研究，项目负责人，编号2014A030310109，2015.01-2017.12，10万

国家自然科学基金面上项目，Aβ蛋白促骨质疏松作用及其介导的破骨细胞-成骨细胞失平衡的机制研究，排名第二，编号81472122，2015.01-2018.12，72万