Tanqi Lou M.D., Ph.D.
Titles
Director of Department of Medicine and Division of nephrology, the Third Affiliated Hospital of Sun Yat-sen University
Research Interests
Glomerular Diseases
Pathogenesis of Diabetic Nephropathy
Chronic Kidney Disease
Hypertension in CKD
Education and Experience
Education
M.S. (Master of Medicine) / Ph.D. (Doctor of Medicine) (successive postgraduate and doctoral program) (1987) Sun Yat-sen University, Medical College, Guangzhou, P.R. China
M.D. (1977) Sun Yat-sen University, Medical College, Guangzhou, P.R. China
Experience
Professor (2001- ). Division of Nephrology, Department of Medicine, the Third Affiliated Hospital of Sun
Yat-sen University, Guangzhou, P.R. China
Associate Professor (1995-2001). Division of Nephrology, Department of Medicine, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China
Attending Physician (1992-1994). Division of Nephrology, Department of Medicine, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China
Honors and Awards
Dr. Lou is a member of the Sstanding Committee of Chinese Medical Doctor Association Nephrologists Branch and the Vice Chair of Guangdong Province Medical Doctor Association Nephrologists Branch. He is a member of Chinese Medical Association Kidney Disease Branch. Dr Lou is an editor of Chinese Journal of Nephrology, Chinese Journal of Nephrology Dialysis & Transplantation, Journal of the American Society of Nephrology（Chinese version）, Nephrol Dial Transplant, NDT （Chinese version）, Chinese Journal of Blood Purification and International Journal of Internal Medicine. He has participated as principal investigator in several studies and serves as a peer reviewer for the Natural Science Foundation of China and National Technology Prize.
Publications
1.Peng H, Li Y, Wang C, Zhang J, Chen Y, Chen W, Cao J, Wang Y, Hu, Z, Lou, T. ROCK1 Induces Endothelial-to-Mesenchymal Transition in Glomeruli to Aggravate Albuminuria in Diabetic Nephropathy. Sci Rep. 2016; 6: 20304.
2.Wang C, Zhang J, Deng W, Gong W, Liu X, Ye Z, Peng H, Lou T. Nighttime Systolic Blood-Pressure Load Is Correlated with Target-Organ Damage Independent of Ambulatory Blood-Pressure Level in Patients with Non-Diabetic Chronic Kidney Disease. PLoS One 2015;10(7):e0131546. doi: 10.1371
3.Wang C, Deng W, Gong WY, Zhang J, Tang H, Peng H, Zhang QZ, Ye ZC, Lou T. High prevalence of isolated nocturnal hypertension in Chinese patients with chronic kidney disease. J Am Heart Assoc 2015 ;4(6):e002025. doi: 10.1161
4.Wang C, Deng W, Gong WY, Zhang J, Zhang QZ, Ye ZC, Lou T. Nocturnal Hypertension Correlates Better With Target Organ Damage in Patients With Chronic Kidney Disease than a Nondipping Pattern. J Clin Hypertens (Greenwich) 2015. doi: 10.1111/jch.12589
5.Wang C, Gong WY, Zhang J, Peng H, Tang H, Liu X, Ye ZC, Lou T. Disparate assessment of clinic blood pressure and ambulatory blood pressure in differently aged patients with chronic kidney disease. Int J Cardiol 2015, 183:54-62
6.Wang C , Li CC, Peng H, Ye Z, Zhang J, Lou tq. Activation of the Nrf2–ARE pathway attenuates hyperglycemia-mediated injuries in podocytes. Cell Physiol Biochem 2014,34:891-902
7.Zhang J, Wang C, Tang Y, Peng H, Ye ZC, Li CC, Lou TQ: Serum immunoglobulin A/C3 ratio predicts progression of immunoglobulin A nephropathy, Nephrology (Carlton) 2013, 18:125-131
8.Wang C, Zhang J, Liu X, Li CC, Ye ZC, Peng H, Chen Z, Lou T: Effect of valsartan with bedtime dosing on chronic kidney disease patients with nondipping blood pressure pattern, J Clin Hypertens (Greenwich) 2013, 15:48-54
9.Wang C, Zhang J, Liu X, Li C, Ye Z, Peng H, Chen Z, Lou T: Reversed dipper blood-pressure pattern is closely related to severe renal and cardiovascular damage in patients with chronic kidney disease, PloS one 2013, 8:e55419
10.Liu X, Pei X, Li N, Zhang Y, Zhang X, Chen J, Lv L, Ma H, Wu X, Zhao W, Lou T: Improved glomerular filtration rate estimation by an artificial neural network, PloS one 2013, 8:e58242
11.Wang C, Liu X, Ke Z, Tang Y, Li CC, Li CM, Ye Z, Zhang J, Lou T: Mesangial medium from IgA nephropathy patients induces podocyte epithelial-to-mesenchymal transition through activation of the phosphatidyl inositol-3-kinase/Akt signaling pathway, Cellular physiology and biochemistry 2012, 29:743-752
12.Peng H, Chen WF, Wu C, Chen YR, Peng B, Paudel SD, Lou TQ: Culture-negative subacute bacterial endocarditis masquerades as granulomatosis with polyangiitis (Wegener's granulomatosis) involving both the kidney and lung, BMC nephrology 2012, 13:174
13.Liu X, Lv L, Wang C, Shi C, Cheng C, Tang H, Chen Z, Ye Z, Lou T: Comparison of prediction equations to estimate glomerular filtration rate in Chinese patients with chronic kidney disease, Internal medicine journal 2012, 42:e59-67
14.Liu X, Cheng MH, Shi CG, Wang C, Cheng CL, Chen JX, Tang H, Chen ZJ, Ye ZC, Lou TQ: Variability of glomerular filtration rate estimation equations in elderly Chinese patients with chronic kidney disease, Clinical interventions in aging 2012, 7:409-415
15.Cheng CL, Tang Y, Zheng Z, Liu X, Ye ZC, Wang C, Lou TQ: Advanced glycation end-products activate the renin-angiotensin system through the RAGE/PI3-K signaling pathway in podocytes, Clinical and investigative medicine 2012, 35:E282
16.Wang C, Liu X, Tang Y, Peng H, Ye Z, Zhang J, Tang H, Lou T: Medium from mesangial cells incubated with aggregated IgA1 from IgA nephropathy patients reduces podocyte adhesion through activation of the renin angiotensin system, Swiss medical weekly 2011, 141:w13304
17.Xun L, Cheng W, Hua T, Chenggang S, Zhujiang C, Zengchun Y, Tanqi L: Assessing glomerular filtration rate (GFR) in elderly Chinese patients with chronic kidney disease (CKD): a comparison of various predictive equations, Archives of gerontology and geriatrics 2010, 51:13-20
18..Wang C, Liu X, Peng H, Tang Y, Tang H, Chen Z, Lou T, Zhang H: Mesangial cells stimulated by immunoglobin A1 from IgA nephropathy upregulates transforming growth factor-beta1 synthesis in podocytes via renin-angiotensin system activation, Archives of medical research 2010, 41:255-260
19.Peng H, Wang C, Ye ZC, Chen YR, Zhang J, Chen ZJ, Yu XQ, Lou TQ: How increased VEGF induces glomerular hyperpermeability: a potential signaling pathway of Rac1 activation, Acta diabetologica 2010, 47 Suppl 1:57-63
20.Lou T, Zhang J, Gale DP, Rees AJ, Rhodes B, Feehally J, Li C, Li Y, Li R, Huang W, Hu B, Leung JC, Lam MF, Lai KN, Wang Y, Maxwell PH: Variation in IGHMBP2 is not associated with IgA nephropathy in independent studies of UK Caucasian and Chinese Han patients, Nephrology, dialysis, transplantation 2010, 25:1547-1554
21.Ye ZC, Wang C, Tang Y, Liu X, Peng H, Zhang H, Lou TQ: Serum IgA1 from patients with IgA nephropathy up-regulates integrin-linked kinase synthesis and inhibits adhesive capacity in podocytes through indirect pathways, Clinical and investigative medicine Medecine 2009, 32:E20-27
22.Wang C, Ye Z, Peng H, Tang H, Liu X, Chen Z, Yu X, Lou T: Effect of aggregated immunoglobulin A1 from immunoglobulin A nephropathy patients on nephrin expression in podocytes, Nephrology (Carlton) 2009, 14:213-218
23.Wang C, Liu X, Ye Z, Zhang J, Tang H, Chen Z, Zhang H, Lou T: Mesangial medium with IgA1 from IgA nephropathy inhibits nephrin expression in mouse podocytes, European journal of clinical investigation 2009, 39:561-567
24.Wang C, Peng H, Tang H, Liu X, Chen Z, Lou T, Yu X: Serum IgA1 from IgA nephropathy patients induces apoptosis in podocytes through direct and indirect pathways, Clinical and investigative medicine 2007, 30:E240-249
25.Lou T, Wang C, Chen Z, Shi C, Tang H, Liu X, Yin P, Yu X: Randomised controlled trial of leflunomide in the treatment of immunoglobulin A nephropathy, Nephrology (Carlton) 2006, 11:113-116
Contact
Division of Nephrology, Department of Medicine,
The Third Affiliated Hospital of Sun Yat-sen University
# 600 Tianhe Street, Guangzhou, Guangdong, China, 510630
E-mail: lou.tq@163.com
Phone: 8620-85252865
