Title
Associate Researcher
3rd Affiliated Hospital of Sun Yat-sen University
Research Interests
SIRT1 signaling pathway in regulation of NAFLD and diabetes.
The regulation of GLP-1 receptor agonist in liver and fat tissue.
Her early work focused on SIRT1 signaling pathway and GLP-1 receptor agonist in regulation of fatty liver and white adipose tissue. She has since been involved in the field of NAFLD and diabetes for which she received National Natural Science Foundation of China (NSFC) support in 2013 and in 2016, respectively. Besides, she received the Pearl River S&T Nova Program of Guangzhou in 2016.
Education and Experience
Education
·Sun Yat-Sen University of Medical Science (2005, MD)
·Sun Yat-sen University (2010, Ph.D)
Residencies
·Resident Physician, 2000.08~2011.12
·Assistant Research Fellow: Endocrinology and Metabolism Department, 2012.01~2014.12
·Associate Researcher: Endocrinology and Metabolism Department, 2014.12~
Basic Research Training
Visiting Graduate Student: Gene regulation Lab, Pennington Biomedical Research Center, Louisiana University, 2007.11~2010.10
Honors and Awards
2007 | Scholarship for Ph.D. Training Collaboration | China Scholarship Council |
2014 | Member of Basic Research and Translational Medicine Group of Chinese Diabetes Society | Chinese Diabetes Society |
2015 | Member of Junior Board of Guangdong Province Diabetes Society | Guangdong Province Diabetes Society |
2016 | Pearl River S&T Nova Program of Guangzhou | Guangzhou Science and Technology Innovation Commission |
Publications
1. Xiaobin Zheng, Fen Xu (co-first author), Hua Liang, Huanyi Cao, Mengyin Cai, Wen Xu, Jianping Weng. SIRT1/HSF1/HSP Pathway Is Essential for Exenatide-Alleviated, Lipid-InducedHepatic Endoplasmic Reticulum Stress. Hepatology. 2017 Sep;66(3):809-824.
2. Fen Xu, Beisi Lin, Xiaobin Zheng, Zonglan Chen, Huanyi Cao, Haixia Xu, Hua Liang, Jianping Weng. GLP-1 receptor agonist promotes brown remodelling in mouse white adipose tissue through SIRT1. Diabetologia. 2016 May;59(5):1059-69.
3. Fen Xu, Xiaobin Zheng, Beisi Lin, Hua Liang, Mengyin Cai, Huanyi Cao, Jianping Ye, and Jianping Weng. Diet-Induced Obesity and Insulin Resistance Are Associated with Brown Fat Degeneration in SIRT1 Deficient Mice. Obesity (Silver Spring). 2016 Mar;24(3):634-42.
4. Yu Zhang, Fen Xu, Hua Liang, Mengyin Cai, Xinqiao Wen, Xiaomao Li and Jianping Weng. Oncology Reports. 2016 Mar; 35(3):1340-8.
5. Erhong Zhang, Fen Xu (co-first author), Hua Liang, Jinhua Yan, Haixia Xu, Zhuo Li, Xingqiao Wen, Jianping Weng. GLP-1 receptor agonist exenatide attenuates the detrimental effects of obesity on inflammatory profile in testis and sperm quality in mice. American Journal of Reproductive Immunology. 2015 Nov;74(5):457-66.
6. Liang H, Xu J, Xu F, Liu H, Yuan D, Yuan S, Cai M, Yan J, Weng J. The SRE Motif in the Human PNPLA3 Promoter (-97 to -88bp) Mediates Transactivational Effects of SREBP-1c. J Cell Physiol. 2015 Sep;230(9):2224-32
7. Zonglan Chen, Weijuan Shao, Fen Xu, Ling Liu, Beisi Lin, Xiaohong Wei, Zhuolun Song, Huogen Lu, I. George Fantus, Jianping Weng, Tianru Jin. Acute Wnt pathway activation positively regulates leptin gene expression in mature adipocytes. Cellular Signalling. 2015 Mar;27(3):587-97.
8. Fen Xu, Zhuo Li, Xiaobin Zheng, Hongxia Liu, Hua Liang, Haixia Xu, Zonglan Chen, Kejing Zeng, and Jianping Weng. SIRT1 Mediates the Effect of GLP-1 Receptor Agonist Exenatide on Ameliorating Hepatic Steatosis. Diabetes. 2014 Nov;63(11):3637-46.
9. Yinli Zhou, Fen Xu (co-first author), Hongrong Deng, Yan Bi, Weiping Sun, Yi Zhao, Zonglan Chen, Jianping Weng. PEDF Expression Is Inhibited by Insulin Treatment in Adipose Tissue via Suppressing 11β-HSD1. PLoS One. 2013 Dec 18;8(12):e84016.
10. Fen Xu, David Burk, Zhanguo Gao, Jun Yin, Xia Zhang, Jianping Weng, and Jianping Ye. Angiogenic Deficiency and Adipose Tissue Dysfunction Are Associated with Macrophage Malfunction in SIRT1-/- Mice. Endocrinology. 2012 Apr;153(4):1706-16.
11. Fen Xu, Zhanguo Gao, Jin Zhang, CA Rivera, Jun Jin, Jianping Weng, Jianping Ye. Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation. Endocrinology. 2010 Jun;151(6):2504-14.
12. Gu H, Xia X, Chen Z, Liang H, Yan J, Xu F, Weng J. Insulin therapy improves islet functions by restoring pancreatic vasculature in high-fat diet-fed streptozotocin-diabetic rats. J Diabetes. 2014 May;6(3):228-36.
Contact
The 3rd Affiliated Hospital of Sun Yat-sen University
600. Tianhe Road, Tianhe District, Guangzhou
Guangdong Province, P.R.China
Postcode:510630
Appointment Phone: +86 20 87677926
